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DECIPHERING NEURODEGENERATIVE DISORDERS

23 – 26 May 2017 Edinburgh

Please use the programme below to view each day of the conference.

Please note that this is the provisional programme and may be subject to change.

For a short biography on each speaker, please click on the speaker’s name.

Opening Plenary

13:30 Introduction to Meeting Chair: Professor Jean Manson
13:30 Opening Address Professor Andrew Morris Chief Scientist, Scottish Government Health Directorates United Kingdom
13:45 Public Health Challenges in Prion Disease: past, present and future Professor Bob Will
Consultant Neurologist who established CJD surveillance within the UK in 1990.  Prof Will was also involved in the identification of vCJD in 1996
National CJD Research & Surveillance Unit, University of Edinburgh United Kingdom
14:15 Cellular and Molecular Aspects of Prion Disease Pathogenesis Professor Bruce Chesebro
Prof Chesebro is the Chief of the laboratory of Persistent Viral Diseases at the Rocky Mountain Laboratories in Montana.  He was elected a Fellow of American Academy of Microbiology in 2011
Rocky Mountain Laboratories, National Institutes of Health, USA United States of America
 14:45 Personal reflections on the effect of dementia Sally Magnusson United Kingdom
15:15 Coffee & Tea Break
15:45 Junior Research Forum  Chair: Dr Alison Green
15:45 Reversible unfolding of infectious prion assemblies reveals the existence of an oligomeric elementary brick  Dr Angélique Igel-Egalon  INRA  France
16:00 Molecular Mechanisms of PrPSc Synaptotoxicity  Dr Cheng Fang  Boston University  United States of America
16:15 Risk modifiers tangled in rapid progression of Alzheimer’s disease  Dr Saima Zafar  Clinical Dementia Center and DZNE, University Medical Center Goettingen (UMG), Goettingen Germany
16:30 MiniBrain for Prion-like diseases: A novel platform to engineer and study 3D human neuroectodermic organoids derived from iPSCs  Mr Ferid Nassor  CEA France
16:45 Pathways of prion spread during early chronic wasting disease in deer  Dr Clare Hoover Colorado State University United States of America
17:00 Amyloid-β accumulation in human growth hormone related iatrogenic CJD patients in the UK  Dr Diane Ritchie University Of Edinburgh United Kingdom
17:15 Stem cell transplantation in the investigation and treatment of genetic Prion Diseases  Miss Kati Frid Hadassah University Hospital, Jerusalem Israel
17:30 Genetic Susceptibility of Free-ranging Cervids to Chronic Wasting Disease in a Recently Infected Region of the United States  Mr William Miller The Pennsylvania State University  United States of America
17:45 Welcome Reception

Mechanisms of Protein mis-folding

09:00 Mechanisms of Protein mis-folding Chair: Dr Andrew Gill
09:00 Single molecule studies of prion aggregation and replication Professor David Klenerman
Physical Scientist involved in research into protein aggregation in Alzheimer’s disease and Parkinson’s disease
University of Cambridge United Kingdom
09:30 The cell membrane and amyloid-β oligomers: a key to understanding Alzheimer’s disease Dr Natalia Carulla
Research Chemist with an interest in amyloid-beta oligomers
Institut Européen de Chimie et Biologie (IECB), Pessac, France, Institute for Research in Biomedicine (IRB Barcalona), Barcelona, Spain Spain
10:00 Prion protein misfolding: beyond a protein-centric view Professor Ilia Baskakov
Professor, Center for Biomedical Engineering and Technology and Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA. Prof Baskakov has an interest in protein mis-folding
Center for Biomedical Engineering and Technology, Department of Anatomy and Neurobiology, University of Maryland School of Medicine United States of America
10:30 Coffee & Tea Break
11:15 Abstract Presentations  “Mechanisms of Neurodegeneration I” Chair: Prof. Neil Mabbott
11:15 Prion protein does not protect neuroblastoma cells from stress, but may affect key cellular properties by modulating growth factor signalling Dr Andrew Gill University Of Edinburgh  United Kingdom
11:30 Key asparagine and glutamine residues promote cross-species prion conversion Dr Christina Sigurdson  UC San Diego United States of America
11:45 ADAM10-mediated shedding of the prion protein: Investigating its mechanism & regulation Ms Luise Linsenmeier  Institute of Neuropathology, University Medical Center HH-Eppendorf, Hamburg  Germany
12:00 Muskelin regulates PrPC vesicle transport and membrane levels and influences prion disease incubation time Dr Susanne Krasemann Institute For Neuropathology  Germany
12:15 α-Synuclein Amyloids Bind To Prion Protein to Facilitate Cell Entry, Cell-To-Cell Spreading And Inhibit Prion Replication Dr Guiseppe Legname SISSA  Italy
12:35 Lunch and Poster Viewing

Mechanisms of Neurodegeneration

14:00 Mechanisms of Neurodegeneration  Chair: Dr. Tara Spires-Jones
14:00 Neurodegeneration in the enteric nervous system-and Prion and Parkinson’s Disease Perspective Associate Professor Victoria Lawson
Neuropathologist with an interest in prion diseases
University of Melbourne, Australia Australia
14:30 Targeting the UPR for treatment of neurodegeneration Professor Giovanna Mallucci
Professor of Clinical Neuroscience with an interest in understanding mechanisms of neurodegeneration
University of Cambridge United Kingdom
15:00 Microglia, protein misfolding and neurodegeneration Professor Jean Manson
Research Scientist studying brain changes in ageing and neurodegenerative diseases including Alzheimer’s disease, particularly the role of synaptic changes.
University of Edinburgh United Kingdom
15:30 Coffee -Tea Break
16:10 Abstract Presentations “Mechanisms of Neurodegeneration II” Chair: Prof. Colin Smith
16:10 Comparison of the neuronal lysosomal response in human neurodegenerative diseases Prof Gabor Kovacs Institute of Neurology/Medical University Vienna  Austria
16:30 Rescuing TACE alpha-secretase activity upon inhibition of PDK1 kinase mitigates prion and Alzheimer’s diseases  Dr Benoit Schneider Inserm UMR-S 1124 – Université Paris Descartes  France
16:45 Expanding roles for PrPCin Alzheimer Disease: an ancient conserved interaction Dr Ted Allison Centre For Prions & Protein Folding Diseases, University Of Alberta  Canada
17:00 Induction of transmissible tau pathology by traumatic brain Injury Dr Roberto Chiesa Istituto di Ricerche Farmacologiche Mario Negri  Italy
17:15 Identification of a highly reactive α-synuclein species in primary neurons exposed to fibrillar α-synuclein. Prof Corinne Lasmezas Scripps Florida United States of America
17:35 End of Sessions

Current Concerns in Prion Disease: Chronic Wasting Disease

09:00 Current concerns in prion disease: Chronic wasting disease Chair: Dr Fiona Houston
09:00 Chronic wasting disease: An agent of global change? Dr Alastair Ward
Senior Lecturer in Zoology with an interest in Ecology and the environment
University of Hull United Kingdom
09:30 Chronic wasting disease: Unveiling modes of transmission Dr Candace Mathiason
Research Scientist with an interest in the mechanisms of CWD prion transmission and in vitro prion detection

Colorado State University United States of America
10:00 CWD in Norway Dr Sylvie L. Benestad
Senior Researcher,  specializing in the identification and characterization of animal prion diseases .
National Veterinary Institute, Norway Norway
10:30 First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques: a work in progress Dr Stefanie Czub
Director of International & OIE Reference Laboratory for BSE  
University of Calgary Faculty of Veterinary Medicine/Canadian Food Inspection Agency Canada
10:45 Coffee & Tea Break
11:15 Abstract Presentations “Disease Transmission and Pathogenesis” Chair: Dr Natalia Carulla
11:15 α-Synuclein prions from MSA patients exhibit similar transmission properties as PrPSc prions Dr Amanda Woerman University Of California, San Francisco United States of America
11:30 Prion replication without host adaptation during interspecies transmissions Dr Jifeng Bian Colorado State University United States of America
11:45 Incongruity between prion conversion and incubation period following co-infection Prof Jason Bartz Creighton University United States of America
12:00 Increased Abundance of M cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility Dr David Donaldson The Roslin Institute United Kingdom
12:15 Epitope identification of toxic propagating strains of Aβ oligomers Prof Neil Cashman University Of British Columbia Canada
12:30 Lunch and Poster Viewing
14:00 Current clinical concerns of prion disease Chair: Prof.Simon Mead
14:00 Funding opportunities for CJD research CJD Foundation
The mission of the Creutzfeldt-Jakob Disease Foundation is to support families affected by Prion Disease, raise awareness, and support medical education and research.
 Debbie Yobs United States of America
14:05 A global collaboration supporting patients, their families and those at increased risk of developing prion diseases. CJD International Support Alliance
The CJD International Support Alliance is a group of international nonprofit organisations whose aim is to support individuals affected/at-risk of prion disease
Suzanne Solvyns / Deana Simpson United States of America
14:35 The prevalance of abnormal prion protein in a UK sample largely unexposed to BSE: The Appendix-3 Survey Results Professor Noel Gill Public Health, England United Kingdom
15:05 What are the Appendix Studies telling us? Professor Richard Knight
Professorial Fellow in Clinical Neurology, with an interest in the clinical presentation, diagnosis and epidemiology of human prion diseases
National CJD Research & Surveillance Unit, University of Edinburgh United Kingdom
15:35 Coffee & Tea Break
16:15 Abstract Presentations on “Clinical Aspects of Prion Disease”  Chair: Prof. Masahito Yamada
16:15 Iatrogenic CJD after human cadaver-sourced growth hormone treatment in France: identifying risk factors associated with susceptibility Ms Laurene Peckeu Institut Du Cerveau Et De La Moelle Épinière (ICM) – Team “alzheimer’s And Prion Diseases “inserm Umr-1127/cnrs Umr 7225  France
16:30 Lessons learned from the systematic public health follow-up of all diagnoses of CJD for surgical risk, in England Dr Katy Sinka Public Health England United Kingdom
16:45 Widening the phenotypic spectrum of sporadic fatal insomnia: clinical findings, results of diagnostic investigations and neuropathological features of new cases. Dr Samir Abu Rumeileh University of Bologna  Italy
17:00 Transmissible prions in the skin of Creutzfeldt-Jakob disease patients Dr Wenquan Zou Case Western Reserve University United States of America
17:15 End Session
19:00 Conference Ceilidh

Diagnostics/Therapeutics

09:00 Diagnostics/Therapeutics Chair: Prof Victoria Lawson
09:00 A new sensitive diagnostic-assay for  vCJD in preclinical and clinical blood samples Dr Chantal Fournier-Wirth
Scientific Director
Univ.Montpellier-Inserm-EFS  France
09:30 Genomic and Epigenomic Associations in Sporadic and Variant CJD Professor Simon Mead
Simon Mead is now a consultant neurologist and Clinical Lead of the UK National Prion Clinic based at the National Hospital for Neurology and Neurosurgery. His clinical interests include cognitive disorders, particularly the prion diseases such as Creutzfeldt-Jakob disease
National Prion Clinic, National Hospital for Neurology and Neurosurgery, London United Kingdom
10:00 Latrogenic CJD related to Dura mater grafts Professor Masahito Yamada
Consultant Neurologist with an interest in prion diseases, particularly iatrogenic CJD
Kanazawa University, Japan Japan
10:30 Coffee &Tea Break
11:00 Promotional Presentation for Prion 2018  Dr Jesus Requena CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS Spain
11:15 Abstract Presentations on “Treatment and diagnosis of prion diseases” Chair: Prof. Richard Knight
11:15 Treatment with a Non-toxic, Self-replicating Anti-prion Delays or Prevents Prion Disease In vivo Dr Charles Mays The University of Texas – Health Science Center at Houston United States of America
11:30 Rational design of anti-PrP antibodies to block prion induced neurodegeneration Dr Assunta Senatore University of Zurich Switzerland
11:45 Detection of mammalian prions by PrP transgenic Drosophila Dr Raymond Bujdoso Cambridge University United Kingdom
12:00 Type-dependant diverse extension patterns of hyperintensity on diffusion-weighted MR images in dura mater graft-associated Creutzfeldt-Jakob disease Dr Kenji Sakai Kanazawa University  Japan
12:15 Early preclinical detection of prions in blood of macaques peripherally infected with the variant CJD agent Dr Luis Concha University Of Texas; Universidad De Los Andes United States of America
12:35 Lunch

Closing Session

14:00 Closing Session Chair: Prof. Jean Manson
14:00 Mechanisms of synapse degeneration in neurodegenerative diseases Dr Tara Spires-Jones
Research Scientist studying brain changes in ageing and neurodegenerative diseases including Alzheimer’s disease, particularly the role of synaptic changes.
University of Edinburgh United Kingdom
14:45 Modelling of neurodegeneration Professor Siddharthan Chandran
Professor Siddharthan Chandran is Director of CCBS. His work spans clinical and laboratory activity in the area of Regenerative Neurology.
University of Edinburgh United Kingdom
15:30 Close of Meeting

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Edinburgh, EH3 8BL
Tel: +44 (0)131 306 0120
Email